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This book retraces the history of the “network paradigm” in immunology — a once-influential scientific theory positing that antibodies form a regulatory, “idiotypic” network within the immune system.
Written by someone who participated in that research wave, the author recounts how early promise, theoretical appeal, and systems-biology enthusiasm led to a surge of research — but over time experimental errors, overinterpretation, and methodological shortcomings caused the paradigm to collapse.
The book uses this case study to reflect more broadly on scientific methodology: how ideas rise and fall, how scientific “hype” can mislead, and how rigorous testing and skepticism are crucial to turn speculation into reliable knowledge.
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Publisher: Birkhäuser Basel
Publishing Year: 2008
ISBN: 9783764383725
Pages: 274